Not every insulin is labeled for use with every device. Choose a starting point to see what's listed together in current U.S. labeling across pumps, automated insulin delivery systems, patch pumps, and connected pens — and where a pharmacy substitution could land a person on an unlisted product. Built to support prescribing, dispensing, and training conversations.
Compatibility is tied to the specific device, not the manufacturer or brand family. An insulin listed for one system may not be listed for another from the same company — for example, Lyumjev is listed for the Tandem t:slim X2 but not for Tandem Mobi.
The devices here are intended for U-100 insulin unless the specific device labeling states otherwise. Concentrated insulins (U-200, U-300, U-500) should not be substituted — using a different concentration can lead to incorrect insulin delivery.
Some devices list specific branded products, biosimilars, or cartridge formats. Do not assume all insulin aspart or all insulin lispro products are interchangeable for device use — the iLet, for instance, lists Fiasp only in the prefilled PumpCart cartridge.
Some insulin–device combinations carry shorter wear-time limits or other use restrictions. Apidra in the Omnipod DASH, for example, is listed for 48 hours rather than 72.
Several rapid-acting biosimilars are FDA-approved. Kirsty (insulin aspart) is the only one designated interchangeable with NovoLog — a pharmacist may substitute it without prescriber sign-off, subject to state law. Merilog (insulin aspart) and Admelog (insulin lispro) are biosimilars but are not interchangeable, so they aren't auto-substituted.
A device names specific products, but a product being absent from that list doesn't automatically make it off-label. Some insulins are labeled for use in any pump compatible with the products the device already lists — to check, refer to the device User Guide and section 2.2 of that insulin's prescribing information. Confirm the dispensed product, formulation, and concentration before use.
Insulin and device choices should weigh clinical needs, safety, cost and coverage, access, dexterity, vision, technology comfort, daily routines, and the preferences of the person using the device.